Placenta as a target of trichloroethylene toxicity
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چکیده
منابع مشابه
Developing brain as a target of toxicity.
The human brain forms over an unusually long period compared to other organs. While most of the basic structure is laid down before birth, neuron proliferation and migration continue in the postnatal period. The blood-brain barrier is not fully developed until the middle of the first year of life. The number of synaptic connections between neurons reaches a peak around age two and is then trimm...
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Trichloroethylene (TCE) and perchloroethylene or tetrachloroethylene (PCE) are high-production volume chemicals with numerous industrial applications. As a consequence of their widespread use, these chemicals are ubiquitous environmental contaminants to which the general population is commonly exposed. It is widely assumed that TCE and PCE are toxicologically similar; both are simple olefins wi...
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Cadmium (Cd) is an important industrial and environmental pollutant that can produce a wide variety of adverse effects in humans and animals. A growing volume of evidence indicates that the vascular endothelium may be one of the primary targets of Cd toxicity in vivo. Studies over the past 20 years have shown that Cd, at relatively low, sublethal concentrations, can target vascular endothelial ...
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Vascular system function involves complex interactions among the vascular endothelium, smooth muscle, the immune system, and the nervous system. The toxic metals cadmium (Cd), arsenic (As), and lead (Pb) can target the vascular system in a variety of ways, ranging from hemorrhagic injury to subtle pathogenic remodeling and metabolic changes. Acute Cd exposure results in hemorrhagic injury to th...
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Rodent experiments have documented neuropathological lesions specifically located in the brainstem when toxic methylmercury (MeHg) exposure occurs at a particular time during brain development. The possible sensitivity of the brainstem to MeHg was explored in the prospective study of a Faroese birth cohort (N = 1,022), most recently examined at age 14 years. In 878 of eligible children (87%), l...
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ژورنال
عنوان ژورنال: Environmental Science: Processes & Impacts
سال: 2020
ISSN: 2050-7887,2050-7895
DOI: 10.1039/c9em00537d